ISSN 1662-4009 (online)

ey0018.10-7 | (1) | ESPEYB18

10.7. Circulating metabolites in progression to islet autoimmunity and type 1 diabetes

S Lamichhane , E Kemppainen , K Trošt , H Siljander , H Hyoty , J Ilonen , J Toppari , R Veijola , T Hyotylainen , M Knip , M Orešič

Diabetologia. 2019;62(12):2287–2297. doi: 10.1007/s00125-019-04980-0This study identified different circulatory metabolite profiles in children who subsequently progress to T1D compared to children who progress to islet autoimmunity but not T1D, and antibody-negative control children.In addition to altered T cell immunity and autoantibody appearance, metaboli...